With our knowledgeable veterinarians we are proud to offer lameness specialists as well as diagnostic tools for all degrees of lameness no matter the difficulty. Coming from many years of experience in the sport horse field; both Dr. Caniglia and Dr. Williamson are equipped with the knowledge first-hand experience with high-end sport horses in a variety of disciplines. From your casual trail horse to high level competition athletes, we come prepared with advanced diagnostic tools to aid in both diagnosis and treatment of any issues that may occur. We also offer rehabilitation for procedures such as kissing spine surgeries and soft-tissue rehabilitation at our facility with our no-run paddocks and riding arena.
Our Sports Medicine Services Include:
At Wolf Creek Equine Hospital, we believe in pursuing innovative regenerative therapies to keep your horse at peak performance. Regenerative therapies offer a wide range of therapeutic benefits to mimic and enhance the body’s own healing capabilities. These therapies can also help to reduce reinjury rates and provide more long-term benefits than more routine anti-inflammatory treatments. At Wolf Creek, we have the ability to collect and process several of these therapies from your horse’s own blood, including Interleukin 1 Receptor Antagonist Protein (IRAP), Platelet Rich Plasma (PRP), and Alpha 2 Macroglobulin (A2M). We also work with VetGraft to use an allogeneic stem cell therapy called PulpCyte.
Click below to learn more about the regenerative therapies we offer, and please call to speak with a veterinarian about which may be right for your horse.
Alpha 2 eq
The Alpha2Eq Orthobiologic therapy is an extraordinary advancement in equine lameness and osteoarthritis science, resulting from years of research to unlock the healing powers of Alpha-2 Macroglobulin (α2M), a naturally occurring molecule in the horse’s bloodstream. This incredible molecule is the body’s natural defense against cartilage breakdown, joint pain, and inflammation.
Unfortunately, this α2M molecule is too large to enter the joint or disc space in large enough quantities to be effective. It’s there, but it can’t get to the site that needs relief. The solution? Astaria Global has patented the first and only AlphaActive™ Concentration Process that isolates and concentrates the Alpha-2 Macroglobulin molecule for use in joint therapy. This process is specifically designed for inflammation and degeneration of joints in horses by concentrating the healing power of α2M in the highest level available on the market today.
Visit alpha2eq.com to learn more.
Defects in articular cartilage can induce osteoarthritis by causing molecular changes in the synovial fluid. Research in molecular biology discovered the major inducer of osteoarthritis was the general inflammatory cytokine interleukin-1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.
In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction. In the IRAP II system, monocytes (a type of white blood cell) bind to the glass beads. The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 24 hours.
IRAP II is used to treat mild to moderate osteoarthritis in animals.
A ready-to-inject connective tissue particulate allograft containing stem cells that is used to treat ligament/tendon injuries, navicular disease, laminitis, and other musculoskeletal injuries in horses.
The PulpCyte® product contains stem cells that have not been duplicated, manipulated or subjected to digestive processes required with cultured products (that manipulate stem cells). This minimal manipulation leaves the stem cells surrounded by their native ECM and viable for 10 Day+ after thawing as verified by propidium iodine & confocal microscopy. These intact unduplicated mesenchymal and hematopoietic cells along with ECM particulates are likely the source of PulpCyte’s regenerative capabilities in connective tissue injury repair. The extracellular matrix includes native growth factors & proteins similar to PRP and IRAP but containing a much higher concentration. These ECM particles, growth factors and proteins likely impart PulpCyte’s favorable anti-inflammatory properties. Safety studies have demonstrated no significant adverse effects such as tumor formation, toxicity, or immune rejection. Horses have been successfully treated for tendon and ligament injuries, navicular bursitis and laminitis. VetGraft’s tissue bank has tracked over 5,000+ treatment doses over the past 5 years and results from a randomized, controlled and blinded 40 horse clinical trial at OSU of the PulpCyte® product in horses with OA and ligament injuries can be found here. https://doi.org/10.3389/fvets.2017.00031
Harvest SmartPrep PRP
Platelet Rich Plasma (PRP) is a biological product created from autologous blood plasma that is centrifuged and separated to achieve a platelet concentration above baseline. Platelets release several beneficial growth factors (PDFG, TGF-B, VEGF, and SDF-1a) that aid in the healing process by promoting blood flow, enhancing collagen synthesis, and signaling stem cells to come to the area of injury. In addition to the high platelet concentration, PRP contains the full complement of clotting factors typically at their normal physiologic levels. Platelets can play a role in fighting infection as activated platelets can bind and capture bacteria and stimulate neutrophils to enhance the immune response. While platelets are the primary component of PRP, preparations may also contain other cellular components such as white blood cells (WBCs) and peripheral stem cells. These components all play a biological role in the healing process and are provided at concentrated levels in PRP, helping optimize the conditions for healing of bone and soft tissue.